Characterization of a Tumor-Microenvironment-Relevant Gene Set Based on Tumor Severity in Colon Cancer and Evaluation of Its Potential for Dihydroartemisinin Targeting

Figure 4

(a) The most differential survival genes were calculated in COAD using GEPIA2. The 500 survival-associated genes were screened and arranged according to values. (b) GO analysis was performed using the most 500 survival-associated genes as the input. The GO terms showed that a proportion of survival-associated genes were concentrated in extracellular environment alterations which is a major structural component of the TME. (c) Venn analysis was carried out to take the intersection between survival-associated genes and extracellular structure organization-related genes from pathway hits of Metascape analysis in COAD.

(a)

(b)

(c)