Prolonged Diuretic and Renoprotective Effects of a Xanthone Obtained from Garcinia achachairu Rusby in Normotensive and Hypertensive Rats

Figure 2

Effect of TDP on renal markers of oxidative stress, endogenous antioxidants factors, and cell biomarkers after 7 days of treatment in rats. (a) Lipid hydroperoxides (LOOH) content, (b) reduced glutathione (GSH) levels, (c) superoxide dismutase (SOD) activity, (d) catalase (CAT) activity, (e) glutathione S-transferase (GST) activity, (f) myeloperoxidase (MPO) activity, (g) N-acetyl-β-D-glucosaminidase (NAG) activity, and (h) nitrite levels in kidney samples collected from normotensive rats (NTR) and spontaneously hypertensive rats (SHR). The results show the mean ± S.E.M. of 6–8 animals per group. Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by Dunnett’s multiple comparisons test. ^∗ when compared with the respective VEH group. when compared with the VEH-treated SHR group. TDP, 1,5,8-trihydroxy-4′,5′-dimethyl-2H-pyrano(2, 3 : 3, 2)-4-(3-methylbut-2-enyl) xanthone.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)