Prolonged Diuretic and Renoprotective Effects of a Xanthone Obtained from Garcinia achachairu Rusby in Normotensive and Hypertensive Rats
Table 1
Urinary parameters were measured after 7 days of treatment with TDP in normotensive and hypertensive rats.
Groups
Urine volume (mL/100 g)
pH
Osmolarity (mOsm/kg H2O)
Na+ (mmol/L)
K+ (mmol/L)
Cl− (mmol/L)
Ca2+ (mg/dL)
NTR
VEH (10 mL/kg)
9.75 ± 0.77
8.39 ± 0.25
362.0 ± 13.06
129.9 ± 8.15
44.57 ± 3.04
335.3 ± 3.45
14.26 ± 0.53
HCTZ (10 mg/kg)
23.13 ± 0.44∗
8.69 ± 0.08
877.4 ± 53.51∗
306.3 ± 13.86∗
98.09 ± 4.59∗
360.0 ± 2.77∗
6.26 ± 0.90∗
TDP (0.1 mg/kg)
14.91 ± 0.69∗
8.75 ± 0.06
520.2 ± 24.66∗
172.7 ± 5.51∗
65.49 ± 3.29∗
324.2 ± 7.92
10.33 ± 0.55∗
SHR
VEH (10 mL/kg)
9.44 ± 0.73
8.58 ± 0.15
399.5 ± 25.05
122.1 ± 8.31
40.45 ± 3.43
316.1 ± 6.61
8.39 ± 0.95
HCTZ (10 mg/kg)
17.52 ± 1.24∗
8.73 ± 0.02
747.8 ± 31.76∗
272.4 ± 12.91∗
76.08 ± 8.43∗
358.0 ± 7.66∗
3.67 ± 0.35∗
TDP (0.1 mg/kg)
15.66 ± 0.91∗
8.61 ± 0.17
507.1 ± 41.52∗
171.3 ± 12.93∗
46.74 ± 3.73
317.0 ± 7.13
5.33 ± 0.80∗
The results show the mean ± S.E.M. of 6–8 animals per group. Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by Dunnett’s multiple comparisons test. ∗ when compared with the respective VEH group. NTR, normotensive rats; SHR, spontaneously hypertensive rats; VEH, vehicle (water plus 1% tween), HCTZ, hydrochlorothiazide, and TDP, 1,5,8-trihydroxy-4′,5′-dimethyl-2H-pyrano(2,3 : 3, 2)-4-(3-methylbut-2-enyl) xanthone.
