Prolonged Diuretic and Renoprotective Effects of a Xanthone Obtained from Garcinia achachairu Rusby in Normotensive and Hypertensive Rats

Table 2

Plasma parameters after treatment with TDP for 7 days in normotensive and spontaneously hypertensive rats.

Groups	Na^+ (mmol/L)	K^+ (mmol/L)	Cl^− (mmol/L)	Ca^2+ (mg/dL)	Uric acid (mg/dL)	Creatinine (mg/dL)	Urea (mg/dL)	AST (U/L)	ALT (U/L)	Nitrite (μM)
NTR
VEH (10 mL/kg)	116.6 ± 9.40	3.09 ± 0.43	224.3 ± 2.79	4.79 ± 0.04	4.61 ± 0.09	0.39 ± 0.01	36.30 ± 2.66	47.63 ± 1.27	46.91 ± 6.16	67.26 ± 3.39
HCTZ (10 mg/kg)	127.5 ± 8.50	4.12 ± 0.46	229.4 ± 4.85	4.36 ± 0.11	4.67 ± 0.17	0.45 ± 0.02	30.45 ± 2.69	45.00 ± 5.10	40.11 ± 3.06	56.48 ± 3.09
TDP (0.1 mg/kg)	117.9 ± 5.88	3.56 ± 0.23	220.8 ± 1.60	4.86 ± 0.16	4.73 ± 0.08	0.38 ± 0.01	35.49 ± 1.39	41.01 ± 1.77	36.60 ± 1.95	60.93 ± 3.62
SHR
VEH (10 mL/kg)	123.3 ± 3.93	3.21 ± 0.87	225.2 ± 2.66	4.97 ± 0.19	4.52 ± 0.18	0.38 ± 0.01	31.91 ± 1.20	47.38 ± 1.85	46.06 ± 2.79	54.71 ± 3.97^#
HCTZ (10 mg/kg)	113.9 ± 7.88	2.85 ± 0.28	222.7 ± 0.57	4.47 ± 0.25	4.60 ± 0.20	0.36 ± 0.01	37.40 ± 0.78	36.27 ± 1.48	47.81 ± 3.47	62.65 ± 2.99
TDP (0.1 mg/kg)	106.3 ± 2.78	2.15 ± 0.41	227.7 ± 3.58	5.10 ± 0.18	4.60 ± 0.09	0.38 ± 0.01	35.46 ± 1.82	48.45 ± 3.99	40.55 ± 2.60	52.40 ± 3.59

The results show the mean ± S.E.M. of 6–8 animals per group. Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by Dunnett’s multiple comparisons test. when compared with the respective VEH group. when compared with the VEH-treated SHR group. NTR, normotensive rats; SHR. spontaneously hypertensive rats; VEH, vehicle (water plus 1% tween); HCTZ, hydrochlorothiazide; TDP, 1,5,8-trihydroxy-4′,5′-dimethyl-2H-pyrano(2,3 : 3,2)-4-(3-methylbut-2-enyl) xanthone.