Research Article

Exploring the Pharmacological Mechanism of Duhuo Jisheng Decoction in Treating Osteoporosis Based on Network Pharmacology

Table 2

Basic information of some key targets of DHJSD against osteoporosis.

UniProt IDGene symbolProtein namesDegree

P35354PTGS2Prostaglandin G/H synthase 2144
P03372ESR1Estrogen receptor98
P0DP23CALM1Calmodulin-196
P07900HSP90AA1Heat shock protein HSP 90-alpha96
P10275ARAndrogen receptor85
P35228NOS2Nitric oxide synthase, inducible80
P23219PTGS1Prostaglandin G/H synthase 174
Q15596NCOA2Nuclear receptor coactivator 270
P24941CDK2Cyclin-dependent kinase 268
P37231PPARGPeroxisome proliferator-activated receptor gamma68
P49841GSK3BGlycogen synthase kinase-3 beta65
Q92731ESR2Estrogen receptor beta62
P20248CCNA2Cyclin-A259
P27487DPP4Dipeptidyl peptidase 457
P07550ADRB2Beta-2 adrenergic receptor52
P19793RXRARetinoic acid receptor RXR-alpha52
Q16539MAPK14Mitogen-activated protein kinase 1451
O14757CHEK1Serine/threonine-protein kinase Chk148
P22303ACHEAcetylcholinesterase34
P08709F7Coagulation factor VII33
Q15788NCOA1Nuclear receptor coactivator 125
P35968KDRVascular endothelial growth factor receptor 224
P25100ADRA1DAlpha-1D adrenergic receptor15
P06401PGRProgesterone receptor15
P31645SLC6A4Sodium-dependent serotonin transporter15
P35372OPRM1Mu-type opioid receptor14
P21728DRD1D (1A) dopamine receptor12
P08235NR3C2Mineralocorticoid receptor12
Q01959SLC6A3Sodium-dependent dopamine transporter12
P27338MAOBAmine oxidase [flavin-containing] B10
Q92934BCL2Bcl2-associated agonist of cell death8
P00918CA2Carbonic anhydrase 28
P42574CASP3Caspase-38
Q04206RELATranscription factor p657
P31749AKT1RAC-alpha serine/threonine-protein kinase6
Q07812BAXApoptosis regulator BAX6
P05412JUNTranscription factor AP-16
O95150TNFSF15Tumor necrosis factor ligand superfamily member 155
P55211CASP9Caspase-94
P24385CCND1G1/S-specific cyclin-D14
P03956MMP1Interstitial collagenase4
P08588ADRB1Beta-1 adrenergic receptor3
P35869AHRAryl hydrocarbon receptor3
P15121AKR1B1Aldo-keto reductase family 1 member B13
Q14790CASP8Caspase-83
P06493CDK1Cyclin-dependent kinase 13
P05177CYP1A2Cytochrome P450 1A23
P08684CYP3A4Cytochrome P450 3A43
P09211GSTP1Glutathione S-transferase P3
Q92819HAS2Hyaluronan synthase 23
P09601HMOX1Heme oxygenase 13
P05231IL6Interleukin-63
P28482MAPK1Mitogen-activated protein kinase 13
P04150NR3C1Glucocorticoid receptor3
Q03181PPARDPeroxisome proliferator-activated receptor delta3
P14672SLC2A4Solute carrier family 2, facilitated glucose transporter member 43
P00441SOD1Superoxide dismutase [Cu-Zn]3
Q9H3D4TP63Tumor protein 633
P15692VEGFAVascular endothelial growth factor A3
Q13085ACACAAcetyl-CoA carboxylase 12
P00533EGFREpidermal growth factor receptor2
P01106MYCMyc proto-oncogene protein2
P02768ALBAlbumin1
P01133EGFPro-epidermal growth factor1
P27361MAPK3Mitogen-activated protein kinase 31