Exploring the Pharmacological Mechanism of Duhuo Jisheng Decoction in Treating Osteoporosis Based on Network Pharmacology

Table 3

The top 10 Gene Ontology (GO) enrichment items.

ID	Description	value	Adjust value	Gene number	GO items
GO:0062197	Cellular response to chemical stress	2.20332E− 36	9.75E − 33	46	Biological process
GO:0010038	Response to metal ion	1.04408 E− 35	2.31E − 32	46	Biological process
GO:0046677	Response to antibiotic	5.44269E− 34	8.03E − 31	43	Biological process
GO:0032496	Response to lipopolysaccharide	8.0729E− 34	8.93E − 31	43	Biological process
GO:0097305	Response to alcohol	1.19658E− 33	1.06E − 30	38	Biological process
GO:0048545	Response to steroid hormone	2.14139E − 33	1.58E − 30	45	Biological process
GO:0002237	Response to molecule of bacterial origin	4.25534E − 33	2.69E − 30	43	Biological process
GO:0006979	Response to oxidative stress	1.67651E − 32	9.27E − 30	47	Biological process
GO:0000302	Response to reactive oxygen species	2.14509E − 32	1.05E − 29	37	Biological process
GO:0031667	Response to nutrient levels	1.65363E − 30	7.32E − 28	47	Biological process
GO:0004879	Nuclear receptor activity	1.2238E − 16	3.33E − 14	14	Molecular function
GO:0098531	Ligand-activated transcription factor activity	1.2238E − 16	3.33E − 14	14	Molecular function
GO:0003707	Steroid hormone receptor activity	1.51056E − 12	2.74E − 10	12	Molecular function
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	1.0407E − 11	1.42E − 09	21	Molecular function
GO:0140297	DNA-binding transcription factor binding	2.02886E − 11	2.21E − 09	23	Molecular function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	5.32777E − 11	4.35E − 09	25	Molecular function
GO:0001216	DNA-binding transcription activator activity	5.59254E − 11	4.35E − 09	25	Molecular function
GO:0019902	Phosphatase binding	4.84351E − 10	3.29E − 08	16	Molecular function
GO:0020037	Heme binding	5.8588E − 09	3.54E − 07	13	Molecular function
GO:0050661	NADP binding	7.53723E − 09	4.10E − 07	9	Molecular function
GO:0045121	Membrane raft	3.10297E − 15	5.63E − 13	25	Cellular component
GO:0098857	Membrane microdomain	3.33964E − 15	5.63E − 13	25	Cellular component
GO:0098589	Membrane region	7.90284E − 15	8.88E − 13	25	Cellular component
GO:0005667	Transcription regulator complex	4.33831E − 10	3.66E − 08	22	Cellular component
GO:0031983	Vesicle lumen	1.59056E − 09	1.07E − 07	19	Cellular component
GO:0090575	RNA polymerase II transcription regulator complex	2.17645E − 09	1.22E − 07	14	Cellular component
GO:0000307	Cyclin-dependent protein kinase holoenzyme complex	1.03807E − 08	5.00E − 07	8	Cellular component
GO:1902554	Serine/threonine protein kinase complex	2.64297E − 08	1.11E − 06	10	Cellular component
GO:0005741	Mitochondrial outer membrane	4.65534E − 08	1.74E − 06	13	Cellular component
GO:0060205	Cytoplasmic vesicle lumen	5.57446E − 08	1.88E − 06	17	Cellular component