Exploring the Pharmacological Mechanism of Duhuo Jisheng Decoction in Treating Osteoporosis Based on Network Pharmacology

Table 4

The enriched 50 possible related pathways of osteoporosis.

ID	Description	value	Adjust value	Gene number
hsa04933	AGE-RAGE signaling pathway in diabetic complications	3.2722E − 31	8.83495E − 29	34
hsa05418	Fluid shear stress and atherosclerosis	8.02758E − 26	6.42442E − 24	34
hsa04657	IL-17 signaling pathway	2.23263E − 21	6.69789E − 20	26
hsa04668	TNF signaling pathway	1.93321E − 20	5.21968E − 19	27
hsa04659	Th17 cell differentiation	1.77974E − 17	3.00331E − 16	24
hsa04210	Apoptosis	5.07009E − 17	8.0525E − 16	26
hsa04218	Cellular senescence	1.70327E − 15	1.9995E − 14	26
hsa04066	HIF-1 signaling pathway	4.55414E − 15	4.72929E − 14	22
hsa01521	EGFR tyrosine kinase inhibitor resistance	1.19998E − 14	1.11722E − 13	19
hsa04115	p53 signaling pathway	3.86218E − 14	3.36383E − 13	18
hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1.25365E − 13	9.95542E − 13	19
hsa04380	Osteoclast differentiation	1.52063E − 13	1.14047E − 12	22
hsa04620	Toll-like receptor signaling pathway	2.26415E − 13	1.5283E − 12	20
hsa04660	T Cell receptor signaling pathway	2.26415E − 13	1.5283E − 12	20
hsa04012	ErbB signaling pathway	6.6254E − 13	4.25919E − 12	18
hsa04151	PI3K-akt signaling pathway	1.24292E − 12	7.80436E − 12	34
hsa04370	VEGF signaling pathway	3.47037E − 12	1.99361E − 11	15
hsa04915	Estrogen signaling pathway	6.54943E − 12	3.60403E − 11	21
hsa04010	MAPK signaling pathway	6.67413E − 12	3.60403E − 11	30
hsa04658	Th1 and Th2 cell differentiation	3.05E − 11	1.55E − 10	17
hsa04068	FoxO signaling pathway	1.6511E − 10	7.96064E − 10	19
hsa04064	NF-kappa B signaling pathway	2.32207E − 10	1.09993E − 09	17
hsa04621	NOD-like receptor signaling pathway	1.2042E − 09	5.16086E − 09	21
hsa04931	Insulin resistance	3.58386E − 09	1.423E − 08	16
hsa04662	B Cell receptor signaling pathway	5.33879E − 09	2.08909E − 08	14
hsa04024	cAMP signaling pathway	5.66891E − 09	2.1641E − 08	22
hsa04910	Insulin signaling pathway	1.80579E − 08	6.58868E − 08	17
hsa04912	GnRH signaling pathway	2.87106E − 08	1.03358E − 07	14
hsa04071	Sphingolipid signaling pathway	1.04592E − 07	3.62048E − 07	15
hsa04014	Ras signaling pathway	4.64353E − 07	1.475E − 06	20
hsa04920	Adipocytokine signaling pathway	5.07934E − 07	1.57635E − 06	11
hsa04062	Chemokine signaling pathway	5.25301E − 07	1.61172E − 06	18
hsa04110	Cell cycle	1.11163E − 06	3.15936E − 06	14
hsa04630	JAK-STAT signaling pathway	1.15731E − 06	3.25493E − 06	16
hsa00140	Steroid hormone biosynthesis	1.30408E − 06	3.59286E − 06	10
hsa04930	Type II diabetes mellitus	9.82492E − 06	2.50258E − 05	8
hsa05323	Rheumatoid arthritis	1.03843E − 05	2.62033E − 05	11
hsa04928	Parathyroid hormone synthesis, secretion and action	3.6295E − 05	8.67227E − 05	11
hsa03320	PPAR signaling pathway	6.67976E − 05	0.000155477	9
hsa04020	Calcium signaling pathway	7.36869E − 05	0.000168606	15
hsa04310	Wnt signaling pathway	9.54755E − 05	0.000213045	13
hsa04929	GnRH secretion	0.000116074	0.000254797	8
hsa04022	cGMP-PKG signaling pathway	0.000147423	0.000321001	13
hsa04015	Rap1 signaling pathway	0.00041579	0.000863564	14
hsa04666	Fc gamma R-mediated phagocytosis	0.00195976	0.003834313	8
hsa04152	AMPK signaling pathway	0.002019554	0.003922874	9
hsa01212	Fatty acid metabolism	0.002098286	0.003989699	6
hsa04923	Regulation of lipolysis in adipocytes	0.002098286	0.003989699	6
hsa04150	mTOR signaling pathway	0.010773083	0.018409699	9
hsa04918	Thyroid hormone synthesis	0.031361971	0.049810189	5