Metabolite Characteristics in Tongue Coating from Damp Phlegm Pattern in Patients with Gastric Precancerous Lesion

Table 2

Identification of significant differential metabolites in tongue coating by comparison of the damp phlegm pattern group and nondamp phlegm pattern group.

Metabolite name	RT (min)	m/z	Mean damp phlegm pattern	Mean nondamp phlegm pattern		VIP	Log fold change	Detection method
Lipids and lipid-like molecules
Cholesterol	25.385	369	0.137	0.081	0.028	1.172	0.749	LC+
(3b,4b,11b,14b)-11-ethoxy-3,4-epoxy-14-hydroxy-12-cyathen-15-al 14-xyloside	148.586	495	0.343	0.470	0.040	3.021	−0.453	LC+
PG(18 : 1(11Z)/22 : 5(4Z,7Z,10Z,13Z,16Z))	230.237	824	0.707	0.521	0.048	2.571	0.440	LC+
3a,7b,12a-Trihydroxyoxocholanyl-Glycine	243.238	466	0.648	0.370	0.028	3.020	0.810	LC+
Pantothenol	65.302	204	0.033	0.019	0.015	1.043	0.811	LC−
Organic acids and derivatives
Glycolic acid	5.611	147	0.043	1.045	<0.01	1.104	−4.598	GC
Ustiloxin D	287.091	495	0.041	0.048	0.045	2.236	−0.238	LC+
Leucyl-Valine	398.503	231	0.174	0.095	<0.01	1.230	0.875	LC+
Sarcosine	369.003	88	0.937	0.592	0.045	2.108	2.108	LC−
L-Proline	334.791	114	0.607	0.275	<0.01	1.175	1.175	LC−
Organic oxygen compounds
D-xylitol	9.799	147	0.001	0.051	0.016	1.363	−5.218	GC
L-Iditol	317.933	181	0.023	0.014	<0.01	2.021	0.740	LC−
Organic nitrogen compounds
L-Carnitine	375.368	162	2.626	3.708	0.028	1.077	−0.498	LC+
Dimethyl dialkyl ammonium chloride	65.873	304	0.008	0.002	<0.01	1.158	1.680	LC+
Benzenoids
N-Undecylbenzenesulfonic acid	103.010	313	0.187	0.238	0.031	1.501	−0.342	LC+
Terephthalic acid	372.085	165	1.273	1.524	<0.01	2.378	−0.260	LC−
Organoheterocyclic compounds
Xanthine	233.387	151	4.516	3.253	0.042	1.854	0.473	LC+
Phenylpropanoids and polyketides
Curcumin	98.995	367	0.019	0.013	0.022	1.749	0.493	LC−
Nucleosides, nucleotides, and analogues
Nelarabine	217.309	296	0.034	0.015	<0.01	2.257	1.140	LC−
Others
Ethanol phosphate	6.715	211	0.000	0.007	0.042	1.166	−4.719	GC
6-deoxyglucitol	10.173	117	0.006	0.277	<0.01	1.747	−5.418	GC
Capric acid	8.355	117	0.006	0.236	<0.01	2.048	−5.262	GC

GC, GC-TOF-MS; LC+, UHPLC-QE-MS positive ion; LC−, UHPLC-QE-MS negative ion.