Metabolite Characteristics in Tongue Coating from Damp Phlegm Pattern in Patients with Gastric Precancerous Lesion

Table 5

Key metabolic pathways identified from the significant differential metabolites in tongue coating between the damp phlegm pattern group and healthy control group.

Pathway	Raw	Impact	Significantly different metabolites
GC-TOF-MS metabolomics analysis
Pantothenate and CoA biosynthesis	0.044	0.180	Pantothenic acid
UHPLC-QE-MS positive ion mode metabolomics analysis
Glycerophospholipid metabolism	0.018	0.231	Phosphatidylethanolamine; LysoPC(18:1(9Z))
Sphingolipid metabolism	0.050	0.017	Sphinganine 1-phosphate; lactosylceramide
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	0.186	0.044	Phosphatidylethanolamine
Arachidonic acid metabolism	0.227	0.026	Leukotriene D4
Valine, leucine and isoleucine degradation	0.446	0.035	3-Methyl-1-hydroxybutyl-ThPP
Starch and sucrose metabolism	0.523	0.013	3-Methoxy-4-hydroxyphenylglycol glucuronide
Pentose and glucuronate interconversions	0.544	0.009	3-Methoxy-4-hydroxyphenylglycol glucuronide
Tyrosine metabolism	0.677	0.007	5,6-Dihydroxyindole
UHPLC-QE-MS negative ion mode metabolomics analysis
Arachidonic acid metabolism	0.042	0.034	Prostaglandin D2