Berbamine Inhibits Cell Proliferation and Migration and Induces Cell Death of Lung Cancer Cells via Regulating c-Maf, PI3K/Akt, and MDM2-P53 Pathways

<div>A schematic of the proposed signaling pathway of the current study. BBM downregulates PI3K and Akt and then downregulates the expressions of c-Maf and MDM2, and c-Maf downregulates the expression of MDM2 and eventually upregulates the expression of p53, leading to cell death.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 10

Figure 10: Berbamine Inhibits Cell Proliferation and Migration and Induces Cell Death of Lung Cancer Cells via Regulating c-Maf, PI3K/Akt, and MDM2-P53 Pathways 

Figure 10 | Berbamine Inhibits Cell Proliferation and Migration and Induces Cell Death of Lung Cancer Cells via Regulating c-Maf, PI3K/Akt, and MDM2-P53 Pathways 