Protective Effects of Anthocleista djalonensis Extracts against Pentylenetetrazole-Induced Epileptic Seizures and Neuronal Cell Loss: Role of Antioxidant Defense System

Table 2

Effects of AFAD or sodium valproate on brain GABA content and GABA transaminase activity in the whole mice brain after chronic administration of pentylenetetrazole-induced kindling.

Group	Dose (mg/kg)	GABA level in brain tissue (µg/g tissue)	GABA-T activity in brain tissue (units/mg tissue)
Vehicle + saline	– + –	272.91 ± 75.24	2.02 ± 0.11
Vehicle + PTZ	– + 90	201.48 ± 38.56	4.52 ± 0.13
AFAD + PTZ	20 + 90	217.42 ± 91.18	3.41 ± 0.12
AFAD + PTZ	40 + 90	221.68 ± 17.54	3.13 ± 0.12
AFAD + PTZ	80 + 90	421.18 ± 62.43	1.57 ± 0.13
AFAD + PTZ	160 + 90	437.24 ± 35.24	1.48 ± 0.10
SVA + PTZ	300 + 90	301.15 ± 27.47	2.26 ± 0.12
AFAD + saline	160 + –	299.68 ± 16.25	2.14 ± 0.11

Results are expressed as mean ± S.E.M. for 10 animals. Data were analysed by one-way ANOVA followed by Bonferroni’s multiple comparison test, , significantly different compared with the pentylenetetrazole-challenged mice. AFAD, standardised active fractions from Anthocleista djalonensis; SVA, 300 mg/kg sodium valproate; PTZ, 30 mg/kg pentylenetetrazole.