Essential Oils Derived from Momordica charantia Seeds Exhibited Antiulcer Activity against Hydrogen Chloride/Ethanol and Indomethacin

Table 5

Effect of MCEO on HCl/EtOH-induced oedema, epithelial disruption, and mucosa erosion in gastric tissues.

Groups	Grading system
	Normal	Oedema and/or vacuolation	Epithelial disruption	Erosion extending to muscularised mucosae
Disease control (distilled water)	0.6 ± 0.2	3.7 ± 0.6	4.5 ± 0.7	3.3 ± 0.7
Ranitidine (100 mg/kg)	1.2 ± 0.2	1.7 ± 0.3	3.5 ± 0.5	1.3 ± 0.8
MCEO (10 mg/kg)	1.3 ± 0.3	2.3 ± 0.3	5.0 ± 0.6	2.0 ± 0.9
MCEO (50 mg/kg)	1.2 ± 0.3	3.0 ± 0.5	4.0 ± 0.6	1.3 ± 0.8
MCEO (100 mg/kg)	1.5 ± 0.2	2.6 ± 0.4	1.5 ± 0.7	0.7 ± 0.7

Data are expressed as mean ± SEM, n = 6, , and . Dunnett’s test as compared with disease control value.