Research Article
Essential Oils Derived from Momordica charantia Seeds Exhibited Antiulcer Activity against Hydrogen Chloride/Ethanol and Indomethacin
Table 7
Effect of MCEO on gastric juice parameters in pylorus-ligation model in rats.
| | Groups | Gastric juice parameter | | Ulcer area (mm2) | Protection (%) | Volume (ml) | pH (unit) | Total acidity (m equiv./L) |
| | Disease control (distilled water) | 12.3 ± 1.7 | — | 3.2 ± 0.4 | 2.2 ± 0.4 | 2927.0 ± 442.1 | | Ranitidine (100 mg/kg) | 6.7 ± 0.6 | 46.0 | 2.2 ± 0.2 | 4.2 ± 0.2 | 2773.0 ± 452.7 | | MCEO (10 mg/kg) | 8.3 ± 1.1 | 32.4 | 2.3 ± 0.4 | 2.9 ± 0.3 | 3020.0 ± 663.8 | | MCEO (50 mg/kg) | 10.7 ± 1.5 | 13.5 | 4.1 ± 1.0 | 4.0 ± 0.2 | 5700.0 ± 59.1 | | MCEO (100 mg/kg) | 7.0 ± 0.7 | 43.2 | 3.0 ± 0.8 | 4.0 ± 0.2 | 3380.0 ± 734.0 |
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Data are expressed as mean ± SEM, n = 6, , , and . Dunnett’s test as compared to disease control value. |
