Evidence-Based Complementary and Alternative Medicine

Review Article

The Effectiveness and Safety of Bushen Huoxue Decoction on Treating Coronary Heart Disease: A Meta-Analysis

Table 3

GRADE assessment of quality of the outcome indicators.
Quality assessmentNo. of patientsEffectQualityImportance
No. of studiesDesignRisk of biasInconsistencyIndirectnessImprecisionOther considerationsBSHXDControlRelative (95% cl)Absolute
Total effective rate
10Randomized trialsSerious1No serious inconsistencyNo serious indirectnessNo serious imprecisionNone401/457 (87.7%)294/444 (66.2%)RR 1.32 (1.23 to 1.43)212 more per 1000 (from 152 more to 285 more)⊕⊕⊕ooo
MODERATE		CRITICAL
65.8%211 more per 1000 (from 151 more to 283 more)
Attack of angina pectoris-frequency (better indicated by lower values)
3Randomized trialsSerious2Serious3No serious indirectnessNo serious imprecisionNone136136—SMD1.24 lower (1.77 to 0.7 lower)⊕⊕oo
LOW		IMPORTANT
Attack of angina pectoris-duration (better indicated by lower values)
3Randomized trialsSerious2Very serious4No serious indirectnessNo serious imprecisionNone136136—SMD1.35 lower (1.9 to 0.81 lower)⊕ooo
VERY LOW		IMPORTANT
Improvement of ECG
7Randomized trialsSerious2No serious inconsistencyNo serious indirectnessNo serious imprecisionNone276/359 (76.9%)193/345 (55.9%)RR1.37 (1.23 to 1.53)207 more per 1000 (from 129 more to 296 more)⊕⊕⊕o
MODERATE		IMPORTANT
57.9%214 more per 1000 (from 133 more to 307 more)
Serum biochemical indicators-TC (mmol/L) (better indicated by lower values)
2Randomized trialsSerious2Very serious5No serious indirectnessSerious6None8585—MD 0.08 lower (0.44 lower to 0.29 higher)⊕ooo
VERY LOW		NOT IMPORTANT
Serum biochemical indicators-TG (mmol/L) (Better indicated by lower values)
2Randomized trialsSerious2Very serious7No serious indirectnessSerious6None8585—MD 0.28 higher (0.13 to 0.43 higher)⊕ooo
VERY LOW		NOT IMPORTANT
Serum biochemical indicators・LDL (mmol/L) (better indicated by lower values)
3Randomized trialsSerious2No serious inconsistencyNo serious indirectnessNo serious imprecisionNone8585—MD 0.23 lower (0.33 to 0.12 lower)⊕⊕⊕o
MODERATE		IMPORTANT
Serum biochemical indicators-HDL (mmol/L) (better indicated by lower values)
2Randomized trialsSerious2Serious8No serious indirectnessSerious6None8585—MD 0.04 lower (0.14 lower to 0.05 higher)⊕ooo
VERY LOW		NOT IMPORTANT
1Blind method of the included study was not mentioned; 2blind method of the included study was not mentioned; 3significant heterogeneity, I2 = 67%; 4significant heterogeneity, I2 = 91%; 5significant heterogeneity, I2 = 94%; 6 the 95% Cl crosses the invalid line; 7significant heterogeneity, I2 = 92%; 8significant heterogeneity, I2 = 72%.