Antidepressant and Anxiolytic Effects and Subacute Toxicity of the Aerial Parts of Psychotria ankasensis J.B.Hall (Rubiaceae) in Murine Models

Figure 7

Liver of a rat that was orally administered 1,000 mg/kg methanolic extract of Psychotria ankasensis (H&E x100 (a), x400 (c)). The structure of the liver is normal, but blood vessels are moderately distended with blood (congested, see (a) broader arrow). Most hepatocytes are normal in structure and are characterized by abundant pink cytoplasm and a large rounded vesicular nucleus (low chromatin density). A few scattered hepatocytes show single-cell necrosis characterized by a condensed, dark-stained nucleus and reduced cytoplasm that stains more eosinophilic (pinker) than in normal hepatocytes (see (c) arrow). Liver of a rat that was administered vehicle as control (H&E x100 (b), x400 (d) shows that the liver is structurally well preserved and predominantly normal; blood vessels are moderately distended (image (b), arrow); a few scattered hepatocytes have a condensed dark-stained nucleus and a reduced amount of cytoplasm that stains more eosinophilic (pinker) are randomly scattered in the organ (see image (d), arrows). These are scattered dead hepatocytes that represent mild, randomly distributed, single-cell hepatocellular necrosis.