Antidepressant and Anxiolytic Effects and Subacute Toxicity of the Aerial Parts of Psychotria ankasensis J.B.Hall (Rubiaceae) in Murine Models

Figure 9

Lung of a rat that was orally administered 1,000 mg/kg methanolic extract of Psychotria ankasensis (H&E x100 (a) x400 (c)) daily for 28 days. Alveoli are empty, but some are expanded (emphysema), while others are reduced in volume (atelectasis); see image (c), and the interalveolar wall is thicker in some parts of the lung than in others (image (c)). Comparatively, the lung of a rat that was administered with vehicle as control (H&E x100 (b)), x400 (d), shows the structure of the lung is well preserved, some alveoli have larger volume (emphysema, image (d), double arrow), while others are collapsed as is described for other groups. This is considered to be a nonlesion as long as the animals had no clinical respiratory signs. Peribranchial lymphoid tissue is prominent (see arrow in images (a) and (b)).