Antidepressant and Anxiolytic Effects and Subacute Toxicity of the Aerial Parts of Psychotria ankasensis J.B.Hall (Rubiaceae) in Murine Models

Table 4

Results from the haematological parameters analyses of the control and treated groups.

Parameter	Control	PAE 100 mg/kg	PAE 300 (mg/kg)	PAE 1000 mg/kg
WBC (10^9/L)	14.92 ± 0.29	14.75 ± 1.65	15.75 ± 1.11	15.60 ± 0.29
LYM (%)	46.85 ± 5.84	66.79 ± 4.43	57.43 ± 4.79	56.69 ± 4.13
MON (%)	8.72 ± 1.58	10.96 ± 0.10	17.80 ± 0.27	19.82 ± 2.60
NEU (%)	37.45 ± 5.05	25.21 ± 8.39	22.90 ± 4.92	22.67 ± 2.70
EOS (%)	6.44 ± 1.02	2.50 ± 1.64	1.73 ± 0.49	3.15 ± 0.4542
BASO (%)	0.36 ± 0.09	0.05 ± 0.01	0.20 ± 0.05	0.28 ± 0.04
LYM# (10^9/L)	2.05 ± 0.46	6.21 ± 3.40	2.98 ± 0.72	2.81 ± 0.43
MON# (10^9/L)	0.55 ± 0.22	0.99 ± 0.50	1.12 ± 0.13	0.82 ± 0.12
NEU# (10^9/L)	1.04 ± 0.10	1.65 ± 0.62	1.53 ± 0.29	1.08 ± 0.09
EOS# (10^9/L)	0.18 ± 0.01	0.15 ± 0.04	0.10 ± 0.03	0.15 ± 0.02
BASO# (10^9/L)	0.01 ± 0.00	0.01 ± 0.00	0.01 ± 0.00	0.01 ± 0.01
RBC (10^12/L)	7.89 ± 0.08	8.07 ± 0.21	8.83 ± 0.60	8.61 ± 0.23
HGB (g/dL)	14.92 ± 0.29	14.75 ± 1.65	15.75 ± 1.11	15.60 ± 0.29
HCT (%)	37.76 ± 0.78	36.80 ± 3.30	40.68 ± 3.70	39.75 ± 1.00
MCV (fL)	47.94 ± 0.82	45.65 ± 2.95	45.88 ± 1.26	46.23 ± 0.30
MCH (pg)	18.86 ± 0.36	18.20 ± 1.60	17.78 ± 0.45	18.1 ± 0.37
MCHC (g/dL)	39.6 ± 0.24	40.00 ± 1.00	39.00 ± 1.08	39.25 ± 0.75
RDW (%)	12.04 ± 0.25	13.05 ± 0.85	14.05 ± 0.32	13.20 ± 1.64
RDW_SD (fL)	44.62 ± 1.38	42.50 ± 1.10	46.25 ± 1.96	42.35 ± 2.61
RDW_CV (%)	12.04 ± 0.26	13.05 ± 0.85	14.05 ± 0.32	13.2 ± 1.64
PLT (10^9/L)	1041.00 ± 60.97	1281.00 ± 574.50	1341.00 ± 142.50	961.00 ± 86.27
MPV (fL)	4.70 ± 0.1924	5.30 ± 0.20	4.65 ± 0.09	4.33 ± 0.16
PDW (fL)	6.88 ± 0.24	8.05 ± 2.35	7.50 ± 0.39	6.25 ± 0.30
PCT (%)	0.48 ± 0.03	0.69 ± 0.33	0.62 ± 0.07	0.41 ± 0.04

Results are presented as mean ± SEM, (n = 5). One-way analysis of variance of all the datasets revealed no statistical significance (). WBC: white blood cell count, LYM: lymphocytes, MON: monocytes, NEU: neutrophils, EOS: eosinophils, BASO: basophils, RBC: red blood cell count, HGB: haemoglobin, HCT: haematocrit, MCH: mean corpuscular haemoglobin, MCHC: mean corpuscular haemoglobin concentration, MCV: mean corpuscular volume, PLT: platelets count, RDW: red blood cell distribution width, RDW_CV: red blood cell distribution width coefficient of variation, MPV: mean platelet volume, PDW: platelet distribution width, and PCT: plateletcrit.