Review Article

A Review on Health Benefits of Malva sylvestris L. Nutritional Compounds for Metabolites, Antioxidants, and Anti-Inflammatory, Anticancer, and Antimicrobial Applications

Table 4

M. sylvestris pharmacological activities.

ActivityModelsExtract/pharmaceutical preparationsFindings

Biochemical profileExtract intake in rats by drinking waterAqueous extract from aerial partsBodyweight dosages (400 and 800 mg/kg) resulted in a significant rise in serum triglycerides, while other lipids, liver enzyme parameters, and glycaemic (alanine and aspartate transaminases, alkaline phosphatase, lactate dehydrogenase) were unaffected [35]

Bioadhesive mucous membranesEx vivo system (mucous membranes prepared buccal region tissue from killed pigs)Aqueous extracts (flowers)Less bioadhesion for epithelial tissue. Not feasible to correlate rehydration effects in this study, anti-irritative and anti-inflammatory [38]

AntiagingQuantitative reverse transcriptase-PCR (polymerase chain reaction) and DNA macro arrayExtract from seedThe rise in antioxidant gene expression [39]

AntimicrobialSequential dilution of plant extracts mixed with 1 ml of DPPHMethanolic extracts (seeds), dichloromethane, and n-hexaneAntioxidant properties by thin-layer chromatography (TLC) qualitative plates test.
For the DPPH test, no low activities for methanolic and n-hexane extracts were observed, and there was no activity for dichloromethane extract [40]

AnticancerMTT testHydroalcoholic leaves extractNotable proliferative reduction of A375 and B16 cancer cell lines [41]

Acetylcholinesterase (AChE)The activity of enzymes evaluated at visible wavelengthsEthanolic extract, essential oil fraction, decoction, and from aerial portionsNo inhibitory observed through the use of the ethanolic extract, and 25% inhibited using 5 mg/ml of plant decoction; 28% of AChE inhibition by 0.1 mg/ml of essential oil [18]