Tong Xie Yao Fang: A Classic Chinese Medicine Prescription with Potential for the Treatment of Ulcerative Colitis

Figure 1

Pharmacological mechanism of Tong Xie Yao Fang in the treatment of ulcerative colitis. Tong Xie Yao Fang can alleviate colitis by activating or inhibiting pathways. +: activate; −: inhibit. IL-17: interleukin-17; IL-1β: interleukin-1β; IL-6: interleukin-6; IL-2: interleukin-2; TNF-α: tumor necrosis factor alpha; IL-4: interleukin-4; IL-10: interleukin-10; PPAR-γ: peroxisome proliferators-activated receptors-γ; TLR: toll-like receptor; HSP70: heat shock protein 70; NF-κB: nuclear transcription factor-κB; VIP: vasoactive intestinal peptide; NPY: neuropeptide Y; ERK: extracellular signal-regulated kinase; CAM: cell adhesion molecule; SOCS: suppressor of cytokine signaling; STAT: signal transducer and activator of transcription; and MSCs: mesenchymal stem cells.