Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation

<div>Similarities and differences of community composition of different species at the genus level. (a) Correlation analysis between BDNF, Glu, and CORT with 12 Enterobacteriaceae with the lowest <svg height="8.68572pt" id="M44" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g></svg> value and (b) left plot: CUMS + BHT (5.4 g/kg) group and right plot: control group. The abundances of <i>Lactobacillus</i> and <i>Bifidobacterium</i>, which are the dominant flora, in the control, CUMS, and BHT groups were high. Note: the ordinate shows 16S flora; the abscissa shows the detection index; red (corr = 1) indicates positive correlation; blue (corr = −1) indicates a negative correlation; and white indicates irrelevant (corr = 0); the darker the color, the stronger the correlation.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 11

Figure 11: Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation 

Figure 11 | Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation 