Research Article
Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation
Table 3
Core targets and topological parameters of BHT of antidepressant effect.
| Target name | Protein name | BC | CC | Degree |
| AKT1 | RAC-alpha serine/threonine-protein kinase | 0.09042456 | 0.56896552 | 29 | MAPK1 | Mitogen-activated protein kinase 1 | 0.11614601 | 0.58928571 | 28 | VEGFA | Vascular endothelial growth factor A | 0.04736493 | 0.54545455 | 24 | INS | Insulin | 0.08146496 | 0.55 | 23 | TNF | Tumor necrosis factor | 0.06669936 | 0.52380952 | 22 | APP | Amyloid-beta A4 protein | 0.14143673 | 0.53658537 | 21 | NOS3 | Nitric oxide synthase, endothelial | 0.01819553 | 0.51162791 | 17 | BDNF | Brain-derived neurotrophic factor | 0.10551453 | 0.52380952 | 17 | HRAS | GTPase HRas | 0.04286645 | 0.50381679 | 16 | HSP90AA1 | Heat shock protein HSP 90-alpha | 0.0302578 | 0.47826087 | 15 | CASP3 | Caspase-3 | 0.02845487 | 0.50381679 | 15 | PTGS2 | Prostaglandin G/H synthase 2 | 0.02909971 | 0.47482014 | 14 |
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