Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation

Table 3

Core targets and topological parameters of BHT of antidepressant effect.

Target name	Protein name	BC	CC	Degree
AKT1	RAC-alpha serine/threonine-protein kinase	0.09042456	0.56896552	29
MAPK1	Mitogen-activated protein kinase 1	0.11614601	0.58928571	28
VEGFA	Vascular endothelial growth factor A	0.04736493	0.54545455	24
INS	Insulin	0.08146496	0.55	23
TNF	Tumor necrosis factor	0.06669936	0.52380952	22
APP	Amyloid-beta A4 protein	0.14143673	0.53658537	21
NOS3	Nitric oxide synthase, endothelial	0.01819553	0.51162791	17
BDNF	Brain-derived neurotrophic factor	0.10551453	0.52380952	17
HRAS	GTPase HRas	0.04286645	0.50381679	16
HSP90AA1	Heat shock protein HSP 90-alpha	0.0302578	0.47826087	15
CASP3	Caspase-3	0.02845487	0.50381679	15
PTGS2	Prostaglandin G/H synthase 2	0.02909971	0.47482014	14