Overexpression of MAL2 Correlates with Immune Infiltration and Poor Prognosis in Breast Cancer

Table 5

Gene sets enriched in high-MAL2-expression phenotype.

MSigDB collection	Name	ES	NES	NOM value	FDR q-value
h.all. v7.4.symbols.gmt	HALLMARK_MYC_TARGETS_V1	0.809	2.089	<0.001	0.002
	HALLMARK_MTORC1_SIGNALING	0.734	2.012	0.002	0.007
	HALLMARK_E2F_TARGETS	0.866	1.964	0.000	0.011
	HALLMARK_MITOTIC_SPINDLE	0.751	1.948	0.004	0.010
	HALLMARK_G2M_CHECKPOINT	0.609	1.941	0.010	0.010
	HALLMARK_UV_RESPONSE_UP	0.618	1.724	0.018	0.049
	HALLMARK_PEROXISOME	0.545	1.581	0.035	0.113
c2.cp.kegg.v7.4.symbols.gmt	KEGG_OOCYTE_MEIOSIS	0.728	2.039	<0.001	0.011
	KEGG_SPLICEOSOME	0.755	1.974	0.004	0.011
	KEGG_CELL_CYCLE	0.785	1.940	0.002	0.010
	KEGG_INSULIN_SIGNALING_PATHWAY	0.574	1.725	0.015	0.051
	KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS	0.575	1.681	0.047	0.055

FDR, false discovery rate; ES, enrichment score; NES, normalized enrichment score; NOM, nominal. Notes: |NES| > 1, FDR q-value < 0.25, and NOM- value < 0.05 were considered significantly different.