The Herbal Constituents in An-Gong-Niu-Huang Wan (AGNH) Protect against Cinnabar- and Realgar-Induced Hepatorenal Toxicity and Accumulations of Mercury and Arsenic in Mice

Figure 2

AGNH’s herbal constituents prevented Hg and As accumulation induced by C + R in the hepatorenal tissues and sera of mice. Mice received saline (vehicle), AGNH (2.5 g/kg), as well as C + R (0.14 g/kg + 0.14 g/kg) orally once daily for 4 weeks, respectively. (a) Hepatic and (b) renal tissues from mice were obtained on day 28. As (As^III and As^V) and Hg contents in the hepatorenal tissues from mice were analyzed by IC-ICP-MS. (c) Blood specimens from mice were also obtained on day 28. The signal intensity of Hg in the sera from mice was measured by ICP-MS. (d) As (As^III and As^V) contents in the sera from mice were analyzed by IC-ICP-MS. Values for continuous variables are described as mean ± standard deviation (SD), n = 12. compared to the saline control group; compared to the C + R coadministration group.

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