Evidence-Based Complementary and Alternative Medicine

Review Article

Comparative Utility of Acupuncture and Western Medication in the Management of Perimenopausal Insomnia: A Systematic Review and Meta-Analysis

Table 2

Trends of major outcomes for sleep and perimenopausal symptoms in Acupuncture (or acupuncture + hypnotic) and comparison with controls in each study.


Author, year	Comparison		Outcome measures for sleep	Outcome measures for perimenopausal symptoms and sex hormone
Author, year	Comparison		PSQI	KI	FSH	E2	LH

Ma 2017 [42]	vs same group at different time-point	Post- vs pretreatment	↓	↓	(-)	↑	—
		3-month follow-up vs pretreatment	↓	↓	(-)	↑	—
		3-month follow-up vs posttreatment	(-)	(-)	(-)	(-)	—
	Acup vs HRT at same time-point	Posttreatment	<	(-)	(-)	<	—
	Acup vs HRT at same time-point	3-month follow-up	<	(-)	(-)	(-)	—
Chen et al. 2013 [43]	vs same group at different time-point	Post- vs pretreatment	↓ (use AIS instead of PSQI)	—	—	—	—
Chen et al. 2013 [43]	Acup vs hypnotic at same time-point	Posttreatment	< (use AIS instead of PSQI)	—	—	—	—
Du et al. 2017 [44]	vs same group at different time-point	Post- vs pretreatment	↓	↓	↓	↑	—
Du et al. 2017 [44]	Acup vs hypnotic at same time-point	Posttreatment	<	<	<	>	—
Kang 2015 [46]	vs same group at different time-point	Post- vs pretreatment	↓	↓	—	—	—
Kang 2015 [46]	Acup vs hypnotic at same time-point	Posttreatment	<	<	—	—	—
Lai 2016 [47]	vs same group at different time-point	Post- vs pretreatment	↓	↓	—	—	—
Lai 2016 [47]	Acup vs hypnotic at same time-point	Posttreatment	(-)	<	—	—	—
Li 2014 [48]	vs same group at different time-point	Post- vs pretreatment	↓	—	—	—	—
Li 2014 [48]	Acup vs hypnotic at same time-point	Posttreatment	<	—	—	—	—
Li et al. 2018 [49]	vs same group at different time-point	Post- vs pretreatment	↓	—	↓	↑	↓
	vs same group at different time-point	Follow-up vs pretreatment	no data	—	no data	no data	no data
	Acup vs hypnotic at same time-point	Posttreatment	<	—	<	>	<
Lu et al. 2014 [50]	vs same group at different time-point	Post- vs pretreatment	↓	—	—	—	—
Lu et al. 2014 [50]	Acup vs hypnotic at same time-point	Posttreatment	<	—	—	—	—
Ma 2014 [45]	vs same group at different time-point	Post- vs pretreatment	↓	—	—	—	—
Ma 2014 [45]	Acup vs hypnotic at same time-point	Posttreatment	<	—	—	—	—
Qin 2018 [51]	vs same group at different time-point	Post- vs pretreatment	↓	—	—	—	—
Qin 2018 [51]	Acup vs hypnotic at same time-point	Posttreatment	(-)	—	—	—	—
Yang et al. 2017 [52]	vs same group at different time-point	Post- vs pretreatment	↓	—	↓	↑	↓
Yang et al. 2017 [52]	Acup vs hypnotic at same time-point	Posttreatment	<	—	>	<	<
Zhang et al. 2017 [53]	vs same group at different time-point	Post- vs pretreatment	↓	↓	—	—	—
Zhang et al. 2017 [53]	Acup vs hypnotic at same time-point	Posttreatment	<	<	—	—	—
Gao et al. 2014 [54]	vs same group at different time-point	Post- vs pretreatment	↓	—	—	—	—
Gao et al. 2014 [54]	Acup + hypnotic vs hypnotic at same time-point	Posttreatment	<	—	—	—	—
Ma 2016 [55]	vs same group at different time-point	Post- vs pretreatment	↓	—	↓	↑	—
Ma 2016 [55]	Acup + hypnotic vs hypnotic at same time-point	Posttreatment	<	—	<	>	—
Zhu et al. 2016 [56]	vs same group at different time-point	Post- vs pretreatment	↓	—	—	—	—
Zhu et al. 2016 [56]	Acup + hypnotic vs hypnotic at same time-point	Posttreatment	(-)	—	—	—	—

↑, statistically increase; ↓, statistically decrease; >, statistically higher/longer/more; <, statistically lower/shorter/less; (-), no statistical difference/no statistical changes; Acup, acupuncture; PSQI, Pittsburgh Sleep Quality Index; KI, Kupperman index; FSH, follicle stimulating hormone; LH, luteinizing hormone; E2, estradiol.