Exploring the Therapeutic Mechanisms of Huzhang–Shanzha Herb Pair against Coronary Heart Disease by Network Pharmacology and Molecular Docking

Table 2

HSHP exerts anti-inflammatory effects on atherosclerosis via inhibiting NF-κB, TNF, and IL-6 signalling pathways.

Drugs	Related pathway	Model/patients	Anti-inflammatory mechanism	Ref
The ethanol extract of hu-zhang	TNF-α, IL-6, MCP-1	RAW264.7 macrophages	TNF-α, IL-6, MCP-1↓	[21]
bioCurcumin, polydatin, liposomal β-caryophyllene	IL-1β, IL-6	HUVECs	IL-1β, IL-6, p16^ink4a ↓, SIRT1↑, miR-146a, miR-21↓	[22]
Polydatin	The phosphorylation of NF-κB p65, JNK, and p38	Macrophages, colitis mice	TNF-α, IL-4, IL-6, COX-2↓	[23]
P. cuspidatum, hawthorn	TNF-α, IL-6	Participants with UA	hs-CRP, TNF-α, IL-6↓, IL-10, and adiponectin↑	[24]
Total flavonoid extract from hawthorn	NF-κBp65-mediated MLCK-MLC	Caco-2 cells	IL-6, IL-8, MCP-1, and IL-1β↓	[25]
Alcohol extract of hawthorn fruit	TNF-α	Rats with CHF	TNF-α, IL-1β↓	[26]

HUVECs: human umbilical vein endothelial cells; JNK: c-Jun N-terminal kinase; COX-2: cyclooxygenase-2; CHF: chronic heart failure; UA: unstable angina.