<i>Lycium barbarum</i> Polysaccharide Ameliorates Heat-Stress-Induced Impairment of Primary Sertoli Cells and the Blood-Testis Barrier in Rat via Androgen Receptor and Akt Phosphorylation

<div>Effects and mechanism of LBP on Sertoli cells and BTB after heat stress. AR could directly interact with PI3K regulatory subunit p85<i>α</i> to activate kinase Akt [<a href="/journals/ecam/2021/5574202/#B37">37</a>, <a href="/journals/ecam/2021/5574202/#B73">73</a>]. LBP maintained the expression of Ki67 and TJ protein and suppressed the re-expression of CK-18 by resisting the decrease of AR and maintaining phosphorylation of Akt in Sertoli cells after heat stress.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 8

Figure 8: <i>Lycium barbarum</i> Polysaccharide Ameliorates Heat-Stress-Induced Impairment of Primary Sertoli Cells and the Blood-Testis Barrier in Rat via Androgen Receptor and Akt Phosphorylation 

Figure 8 | Lycium barbarum Polysaccharide Ameliorates Heat-Stress-Induced Impairment of Primary Sertoli Cells and the Blood-Testis Barrier in Rat via Androgen Receptor and Akt Phosphorylation 