Antiamnesic and Neuroprotective Effects of an Aqueous Extract of Ziziphus jujuba Mill. (Rhamnaceae) on Scopolamine-Induced Cognitive Impairments in Rats

Table 3

Effect of Z. jujuba extract on some oxidative stress markers in the prefrontal cortex.

Treatment	Oxidative stress markers in the prefrontal cortex
	GSH (μmol/g)	MDA (mmol/g)	SOD (unit/min/g)	Nitrite (mmol/g)	Total protein (μg/ml)
DW + DW	1134.1 ± 102.4	4.5 ± 0.5	61.3 ± 5.1	169.6 ± 1.7	2170.9 ± 36.1
SCO + DW	232.6 ± 33.7^c	13.3 ± 2.3^c	212.6 ± 373.2^c	613.6 ± 2.8^c	331.6 ± 32.2^c
SCO + DZ	487.3 ± 49.2	7.2 ± 2.6	126.5 ± 16.6	402.7 ± 2.4	1202.2 ± 33.9
SCO + TA	720.9 ± 75.2	6.2 ± 1.1	59.4 ± 7.3	530.4 ± 3.2	1404.1 ± 25.1
SCO + E29	848.1 ± 87.9	9.5 ± 0.7	271.8 ± 24.1	370.4 ± 3.5	958.6 ± 28.4
SCO + E57	710.4 ± 79.9	9.5 ± 1.2	395.1 ± 48.3	366.4 ± 2.8	865.3 ± 26.7
SCO + 114	538.1 ± 56.9	5.3 ± 0.5	321.5 ± 27.5	425.2 ± 1.1	683.9 ± 32.4

Each value represents the average ± SEM; n = 7. ^cvs. normal control. ; ; vs. negative control; DW: distilled water (10 ml/kg); SCO: scopolamine (1 mg/kg); DZ: donepezil (1.2 mg/kg); TA: tacrine (10 mg/kg); E29, E57, and E114: aqueous extract of Z. jujuba at respective doses of 29, 57, and 114 mg/kg. DW + DW: normal control group; SCO + DW: negative control group; SCO + DZ: positive control group with donepezil; SCO + TA: positive control group treated with tacrine; SCO + E29-E114: test groups treated with Z. jujuba extract; GSH: reduced glutathione; MDA: malondialdehyde; SOD: superoxide dismutase.