Qindan Capsule Attenuates Myocardial Hypertrophy and Fibrosis in Pressure Overload-Induced Mice Involving mTOR and TGF-β1/Smad Signaling Pathway Inhibition

Figure 2

Effects of QC on myocardial hypertrophy and fibrosis after TAC surgery in mice. (a) Representative images of hearts, HE stain, and Masson’s trichrome staining of mice left ventricles at the end of 8 weeks after TAC surgery. Scale bar, 50 μm. (b) Ratios of heart weight to tibial length (HW/TL) and (c) ratios of lung weight to tibial length (LW/TL) were measured 8 weeks after TAC surgery. (d) Cross-sectional area of cardiomyocytes was quantified with HE sections. (e) Cardiac fibrosis area was quantified with Masson’s trichrome-stained sections. Relative mRNA levels of (f) ANP, (g) BNP, and (h) β-MHC were evaluated using RT-PCR. vs. sham group. and vs. TAC group. Data are presented as mean ± SEM and n = 5.

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