Metabolomic Analysis of the Urine from Rats with Collagen-Induced Arthritis with the Effective Part of Caulophyllum robustum Maxim

Table 1

The identification of potential biomarkers and their metabolic pathways.

No.	Rt (min)	m/z	Formula	Description	Metabolic pathways	Trend
1	0.90	153.0662	C7H8N2O2	N1-methyl-4-pyridone-3-carboxamide	Vitamin metabolism	↓
2	11.93	101.0712	C4H10N2O2	2,4-Diaminobutyric acid	Amino acid neurotransmitter metabolism	↑
3	12.37	413.2715	C24H38O4	7-Hydroxy-3-oxocholanoic acid	Bile acid metabolism	↑
4	11.68	301.1428	C16H22O4	alpha-CEHC	Vitamin metabolism	↑
5	4.95	160.0403	C9H7NO2	2-Indolecarboxylic acid	Tryptophan metabolism	↓
6	5.94	429.1970	C24H32O8	17-beta-estradiol-3-glucuronide	Pentose and glucuronate interconversions	↑
7	12.79	433.3698	C27H48O	5b-Cholestanol	Cholesterol metabolism	↑
8	4.32	180.0670	C9H9NO3	Hippuric acid	Phenylalanine metabolism	↓
9	0.90	151.0621	C5H10O5	D-Ribose	Pentose phosphate pathway	↑
10	4.32	105.0350	C7H6O2	Benzoic acid	Phenylalanine metabolism	↓
11	11.69	205.0868	C12H14O4	Monoisobutyl phthalic acid	Energy metabolism	↑
12	12.62	419.3532	C27H48O3	5-b-cholestane-3a,7a,12a-triol	Cholesterol metabolism	↑
13	3.66	156.0408	C 8H7NO	Indoxyl	Tryptophan metabolism	↓
14	164.07	1.2379	C9H11NO3	L-Tyrosine	Tyrosine metabolism	↓
15	461.40	2.04602	C29H52O	Stigmastanol	Cholesterol metabolism	↑
16	109.03	3.07623	C6H6O2	11-Hydroquinone	Tyrosine metabolism	↓