FTZ Ameliorates Diabetic Cardiomyopathy by Inhibiting Inflammation and Cardiac Fibrosis in the Streptozotocin-Induced Model

Figure 8

FTZ inhibited the expressions of fibrotic factors in C3H/10T1/2 cells. C3H/10T1/2 cells were treated with TGF-β1 (50 ng/ml) and different FTZ (1 μg/ml, 10 μg/ml, and 100 μg/ml) for 12 h or 24 h. (a) The mRNA levels of Col1al, Col3al, and Acta2 in cells were tested by Q-PCR. (b) The protein changes of α-SMA, CTGF, p-AKT, AKT, p-ERK, ERK, p-STAT3, and STAT3 in cells were tested by Western blot. n = 3. , , and .

(a)

(b)