Pharmacological Mechanisms Underlying the Therapeutic Effects of Danhong Injection on Cerebral Ischemia

Figure 4

Topological analysis of the protein-protein interaction network. (a) Overlapping target proteins Venn diagram between DHI targets, DQs targets, and IS targets. (b) Overlapping KEGG signaling Venn diagram between DHI and DQs. (c) PPI network constructs based on 8 overlapping targets of DQs associated with IS. Herein, 1162 protein nodes were obtained. After extracted by top 20^th percentile of DC and top 6^th percentile BC, a total of 70 nodes were obtained. (d) Core module identified by PPI network analysis. 5 overlapping protein associated with PI3L/Akt signaling are marketed as red squares.

(a)

(b)

(c)

(d)