Aboriginal Bacterial Flora in the Uricase-Deficient Rat Gut is Not the Main Factor Affecting Serum Uric Acid

Figure 8

Bacterial abundance of the wild-type (WT) rats and Uox^-/- rats’ stool at phylum (a), class (b), order (c), family (d), genus (e), and species (f) levels (mean ± SE, n = 6). The top 10 bacteria in the WT rats’ stool were listed in order, and those in the normal Uox^-/- rats (Uox^-/-−1) and the Uox^-/- rats treated with the combination of antibiotics (Uox^-/-−2, ampicillin (90 mg/kg) and ciprofloxacin (150 mg/kg) for 5 days) were also listed. The top 10 in the Uox^-/-−2 group were listed without analysis because more than 99% of bacteria were inhibited or killed by antibiotics. (a) The top 10 bacteria at the phylum level covered 99.75% of all bacteria in the WT rats and 99.65% in the normal Uox^-/- rats; (b) the top 10 at the class level covered 99.50% in the WT rats and 96.30% in the normal Uox^-/- rats; (c) the top 10 at the order level covered 96.29% in the WT rats and 91.61% in the normal Uox^-/- rats; (d) the top 10 at the family level covered 92.21% in the WT rats and 80.91% in the normal Uox^-/- rats; (e) the top 10 at the genus level covered 80.14% in the WT rats and 58.72% in the normal Uox^-/- rats; and (e) the top 10 at the species level covered 76.51% in the WT rats and 48.44% in the normal Uox^-/- rats. vs. WT, Student’s t-test.

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