Aboriginal Bacterial Flora in the Uricase-Deficient Rat Gut is Not the Main Factor Affecting Serum Uric Acid
Table 2
The top 10 species identified in rat stool.
No.
WT
Uox-/- −1
Uox-/- −2∗
Species
Abundance (%)
Species
Abundance (%)
Species
Abundance (%)
1
Vibrio_parahaemolyticus
24.40
Lactobacillus_johnsonii
16.25
Lactobacillus_johnsonii
24.15
2
Cronobacter_sakazakii
14.84
Cronobacter_sakazakii
11.31
Lactobacillus_H_vaginalis_A
19.87
3
Cronobacter_malonaticus
11.32
Vibrio_parahaemolyticus
5.85
Lactobacillus_B_apodemi
19.37
4
Lactobacillus_johnsonii
7.28
Prevotella_conceptionensis
5.40
Rothia_nasimurium
10.65
5
Lactobacillus_B_apodemi
5.08
Lactobacillus_H_vaginalis_A
4.55
Pseudomonas_E_sihuiensis
2.00
6
Salmonella_enterica
3.82
Kineothrix_alysoides
4.00
Cronobacter_sakazakii
1.95
7
Cronobacter_dublinensis
3.45
Salmonella_enterica
3.43
Cronobacter_malonaticus
1.85
8
Lactobacillus_H_vaginalis_A
2.68
Schwartzia_succinivorans
2.96
Vibrio_parahaemolyticus
1.335
9
Chryseobacterium_sp002899825
2.00
Saccharimonas_aalborgensis
2.93
Enterococcus_rotai
1.24
10
Eubacterium_R_sp000436835
1.66
Prevotella_copri
2.73
Saccharimonas_aalborgensis
1.04
Total (349)
76.50
Total (361)
59.40
Total (415)
83.45
More than 99% of bacteria in stool were inhibited or killed in the Uox-/-−2 group treated by the combination of antibiotics. WT rats, wild-type rats; Uox-/-−1, normal Uox-/- rats; Uox-/-−2, Uox-/- rats treated with combinatorial antibiotics (ampicillin (90 mg/kg) and ciprofloxacin (150 mg/kg) for 5 days).
