Antiobesity and Antidiabetic Effects of Portulaca oleracea Powder Intake in High-Fat Diet-Induced Obese C57BL/6 Mice

Table 4

Blood serum lipid parameter of C57BL/6 mice fed the experimental diets.

Item	Group^(1)
	CON	HFD	HFD + PO5%	HFD + PO10%
TC (mg/dL)	59.2 ± 3.4^(6)b	81.8 ± 6.4^a	89.5 ± 5.5^a	92.6 ± 0.5^a
HDL-cholesterol (mg/dL)	44.3 ± 3.0^c	58.3 ± 5.8^b	75.0 ± 4.9^a	72.5 ± 0.2^a
LDL-cholesterol (mg/dL)	6.3 ± 0.3^c	11.7 ± 0.4^a	11.3 ± 0.8^ab	9.8 ± 0.7^b
Triglyceride (mg/dL)	43.5 ± 1.0^c	59.5 ± 1.4^a	46.0 ± 3.7^bc	51.5 ± 1.9^b
TG/HDL-cholesterol	1.01 ± 0.05^a	1.08 ± 0.08^a	0.64 ± 0.07^b	0.71 ± 0.03^b
AI^(2)	0.34 ± 0.01^b	0.43 ± 0.03^a	0.29 ± 0.03^b	0.28 ± 0.01^b
CRF^(3)	1.34 ± 0.01^b	1.43 ± 0.03^a	1.29 ± 0.03^b	1.28 ± 0.01^b
Insulin (μU/ml)	18.8 ± 2.85^b	39.3 ± 4.92^a	39.4 ± 2.68^a	27.5 ± 5.23^ab
HOMA-IR^(4)	4.2 ± 0.7^b	10.6 ± 2.2^a	7.6 ± 1.4^ab	5.2 ± 1.5^b
ALT (U/L)^(5)	53.0 ± 8.7^b	135.5 ± 14.0^a	46.8 ± 3.5^b	40.3 ± 4.5^b

⁽¹⁾CON: control diet; HFD: high fat diet; HFD + PO5%: high fat diet + 5% P. oleracea powder; HFD + PO10%: high fat diet + 10% P. oleracea powder. ⁽²⁾AI (atherogenic index) = total cholesterol-HDL-cholesterol/HDL-cholesterol. ⁽³⁾CRF (cardiac risk factor) = total cholesterol/HDL cholesterol. ⁽⁴⁾HOMA-IR (homeostasis model assessment of insulin resistance) = fasting insulin level (μU/mL)fasting glucose level (mg/dL)/405. ⁽⁵⁾Alanine aminotransferase.⁽⁶⁾Values are the mean ± SE (n = 8/group). ^(a–c)Values with a different superscript in the same row are significantly different at by Duncan’s multiple range test.