Review Article

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

Table 2

Chemical compounds isolated from Centaurea spp.

EntryCentaurea spp.Phytochemical constituentsReferences

1C. alexanderinaSesquiterpene lactones and flavonoids (kaempferol 3-O-rutinoside, rutin, apigenin 7-O-galacturonic acid methyl ester, apigenin 7-O-β-D-glucoside, astragalin, centaurein, vicenin, vitexin, isovitexin, kaempferol, apigenin, quercetin, jaceosidin, and nepetin)[75, 104, 115, 116]

2C. asperaSesquiterpene lactones (dehydromelitensin, melitensin, isomelitensin, eudesmanolides, and dihydrostenophyllolide) and flavonoids (6-methoxyluteolin (nepetin), 6-methoxyacacetin (pectolinarigenin), 6-methoxyapigenin (hispidulin), and 6-methoxychrisoeriol (jaceosidin)).[52, 116118]

3C. bornmuelleriFlavonoids (afzelin, astragalin, isorhamnetin, apigenin, quercetin, luteolin, and kaempferol), phenolic acids (caffeoylquinic acids and chlorogenic acid), sterol (stigmast-4-en-3gamma-ol), and lignans (arctiin, arctigenin, matairesinol, and matairesinoside)[67, 92, 119]

4C. bruguieranaSesquiterpene lactones (cnicin and dehydromelitensin-8-acetate) and flavonoids (kaempferol, rutin, quercetin, cirsimaritin, cirsilinelol, and eupatilin)[77, 104, 112, 113, 120123]

5C. calcitrapaSterols, sesquiterpene lactones and their closely related group of triterpenoids, lignans, flavonoids (apigenin, luteolin, scutellarein, chrysoeriol, nepetin, jaceosidin, eupatorin, kaempferol, kaempferide, jaceidin, and centaureidin), alkaloids (stizolphine and choline), and phenolic acids (derivatives of hydroxycinnamic acids: p-coumaric, ferulic, caffeic, and chlorogenic acid; derivatives of hydroxybenzoic acids: p-hydroxybenzoic, protocatechuic, gallic, and gentisic acid)[124132]

6C. centauriumFatty acids (11, 14-eicosadienoic acid methyl ester, 9-octadecenoic acid methyl ester, and 9-octadecenoic acid) and terpenes (cypirene, α-zingiberene, β-farnesene, β-santalene, β-bisabolene, β-himachalene, and azulene)[69]

7C. corubionensisHas not been fully characterized

8C. depressaPhenolic compounds, condensed tannins, flavonoids (luteolin, kaempferol, scutellarein 7-β-D-glucuronoside, scutellarein 5-β-D-glucuronoside, quercetin, isoquercitrin, quereimeritrin, and apigenin), monoterpenoid (piperitone), sesquiterpenoid (elemol), and sesquiterpene lactones (solstitialin A and acetyl solstitialin)[70, 90, 92, 133137]

9C. drabifoliaFlavonoids, sesquiterpene lactones (belonging to the guaiane class; centaurea lactone, cynaropicrin, aguerin B, 8α-isovaleryloxyzaluzanin C, 8α-acetoxyzaluzanin C, and 4β,15-dihydro-3-dehydrosolstitialin A), and phenolic compounds (protocatechuic acid, 5-caffeoylquinic acid, 5-feruloylquinic acid, orientin, vitexin, quercetin, quercetin-3-O-glucoside, patuletin-O-hexoside, luteolin, luteolin-7-O-rutinoside, luteolin-7-O-glucoside, isovitexin, apigenin, and hispidulin)[138142]

10C. fenzliiFlavonoids (cirsiliol, isorhamnetin, hispidulin, and cirsimaritin)[95]

11C. horridaFlavonoids (horridin, apigenin, rutin, apigenin-3-Ο-glucuronide, kaempferol-3-O-glucuronide, apigenin-8-C-α-L-arabinoside, apigenin-6-C-α-L-arabinoside, apigenin-7-Ο-β-D-glucoside, apigenin6,8-di-C-β-D-glucoside, scutelarein-7-O-β-D-glucoside, kaempferol-3-O-β-D-glucoside, kaempferol-3-O-α-L- rhamnoside, vitexin, isovitexin, orientin, schaftoside, hispidulin, fisetin, quercetin, quercetin-3-O-α-L-rhamnoside, and quercetin-3-O-β-D-galactoside), lactones, phenolic acids, pentacyclic triterpenes, sterol glucoside, and Q acid derivatives[104, 143146]

12C. hypoleucaSesquiterpene lactones (centaurepensin, acroptillin, cynaropicrin, janerin, linichlorin, and repin) and phenolic compound (catechin and chlorogenic acid)[72, 126, 147150]

13C. karduchorumPhenolic compounds (chlorogenic acid, apigenin, and luteolin glycosides)[73, 150, 151]

14C. kotschyiSesquiterpene lactones (germacrene D, β-caryophyllene, β-cedrene, β-bisabolene, and bicyclogermacrene), phenolic compounds, and flavonoid (patuletin-7-O-glucoside)[70, 116, 152, 153]

15C. papposaPhenolic acids (quinic acid, malic acid, gallic acid, protocatechuic acid, chlorogenic acid, caffeic acid, ferulic acid, salicylic acid, vanillic acid, coumarin, syringic acid, apigenin, and apigetrin), flavonoids, and terpenes[8, 154, 155]

16C. patulaPhenolic compounds (protocatechuic acid, caffeic acid, 5-feruloylquinic acid, orientin, vitexin, patuletin-O-hexoside, luteolin-7-O-glucoside, isovitexin, quercetin, apigenin, hispidulin, and luteolin), sesquiterpenes (spathulenol), and diterpene alcohol (phytol)[141, 156]

17C. pulchellaPhenolics content, condensed tannins, and fatty acid (linoleic acid, α-linoleic acid, and palmitic acid)[70]

18C. salignaFlavonoids (rutin, hesperidin, quercetin, luteolin, kaempferol, and apigenin) and phenolic compounds (rosmarinic acid and p-coumaric acid)[74]

19C. tchihacheffiiPhenolic compounds[70]

20C. triumfettiiPhenolic compounds (chlorogenic acid, ferulic acid, p-coumaric acid, and caffeic acid)[14, 150]

21C. urvilleiFlavonoids (naringenin-7-O-β-D glucuronopyranoside, 6-hydroxykaempferol-7-O-β-D glucuronopyranoside, hispidulin-7-O-β-D-glucuronopyranoside, apigenin-7-O-β-D-methylglucuronopyranoside, hispidulin-7-O-β-D-methylglucuronopyranoside, hispidulin-7-O-β-D-glucopyranoside, apigenin-7-O-β-D-glucopyranoside, kaempferol, apigenin, luteolin, eriodictyol-7-O-β-D-glucuronopyranoside, arbutin, salidroside, and 3,5-dihydroxyphenethyl alcohol-3-O-β-D-glucopyranoside)[70, 92, 157]