Preparation and Characterization of MUC-30-Loaded Polymeric Micelles against MCF-7 Cell Lines Using Molecular Docking Methods and In Vitro Study

Table 4

Binding energy of MUC-30 and tamoxifen with targeted proteins from AutoDock 4.

Ligands	Targeted proteins	PDB IDs	Binding affinity (kcal/mol)	IC50 for MUC-30 (μM)
MUC-30	ERα	3ERT	−8.6	0.49
Tamoxifen	ERα	3ERT	−10.5	0.021
MUC-30	PR	4OAR	−6.0	42.54
Tamoxifen	PR	4OAR	−7.3	4.28
MUC-30	EGFR	2J6M	−8.7	0.40
Tamoxifen	EGFR	2J6M	−7.8	2.04
MUC-30	PgP	6QEX	−5.0	218.01
Tamoxifen	PgP	6QEX	−5.6	80.79
MUC-30	NF-kB	1SVC	−7.1	6.69
Tamoxifen	NF-kB	1SVC	−5.3	125.32
MUC-30	HER2	3WSQ	−6.2	29.18
Tamoxifen	HER2	3WSQ	−8.2	0.95