Comparison of Effects and Brain-Gut Regulatory Mechanisms of Acupuncture and Flunarizine for Migraine: Study Protocol for a Randomized Controlled Trial

Table 1

Data measurements at each time point.

Measurements	Enrollment	Allocation	Postallocation				Closeout
	−4 weeks	0 week	1 week	2 weeks	3 weeks	4 weeks	16 weeks
Eligibility screen	×
Informed consent	×
Physical examination	×
Allocation		×
Headache diary	×	×	×	×	×	×	×
Visual analog scale		×				×	×
Gastrointestinal symptom rating scale		×				×	×
Beck anxiety inventory		×				×	×
Beck depression inventory		×				×	×
Migraine-specific quality of life questionnaire		×				×	×
Magnetic resonance imaging		×				×	×
Gut microbiota examination		×				×	×
Adverse events			×	×	×	×	×