Electroacupuncture Alleviates Hyperalgesia by Regulating CB1 Receptor of Spinal Cord in Incisional Neck Pain Rats

Figure 1

EA increases thermal pain threshold (TPT) in rats with neck incisional pain. (a) Schematic diagram of experimental procedures of EA intervention and TPT measurements: TPT was measured before neck incision, and 4, 24, and 48 h after EA intervention. (b) Histograms showing the effect of EA at Futu(LI18), Hegu (LI14)-Neiguan(PC6), and Zusanli(ST36)-Yanglingquan(GB34) on the change rate of TPT at different time points after modeling (mean ± SD, n = 13/group). The change rate of TPT (TPT%) = (TPT after neck incision − TPT before neck incision)/TPT before neck incision × 100%. Repeated measures ANOVA revealed that TPT% was significantly decreased from 4 to 48 h after modeling (vs the control group) and considerably increased at 24 and 48 h after EA of LI 18 and LI4-PC6, rather than EA of ST36-GB34 (vs the model group).  < 0.05, vs the control group, ^{^} < 0.05, vs the model group, ^# < 0.05, vs the EA LI18 group, all by the LSD test.

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