Research Article
Effect of Curcumin on Diabetic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Clinical Trials
Table 2
Effect of curcumin supplementation on outcomes.
| Outcomes | No. of studies | Sample size | Heterogeneity | Analysis model | WMD (95% CI) | value | I2 | P heterogeneity |
| Renal function | SCr | 4 | 190 | 0% | 0.648 | Fixed | −0.16 (−0.3 to −0.02) | 0.029 | BUN | 2 | 86 | 0% | 0.601 | Fixed | 1.10 (−1.72 to 3.92) | 0.446 | PRO | 4 | 237 | 86.90% | <0.01 | Random | 0.09 (−0.73 to 0.92) | 0.614 |
| Lipid profile | TC | 4 | 190 | 0% | 0.426 | Fixed | −10.13 (−17.84 to −2.14) | 0.01 | TG | 4 | 190 | 0% | 0.661 | Fixed | 3.42 (−6.93 to 13.22) | 0.495 | HDL-C | 3 | 139 | 0% | 0.587 | Fixed | 1.16 (−1.55 to 3.87) | 0.402 | LDL-C | 3 | 139 | 77.20% | 0.012 | Random | −1.06 (−17.89 to 15.77) | 0.902 |
| Blood pressure | SBP | 4 | 244 | 33.50% | 0.212 | Fixed | 3.94 (1.86 to 6.01) | <0.01 | DBP | 4 | 244 | 92.30% | <0.001 | Random | 0.21 (−5.64 to 6.05) | 0.944 |
| Glycemic control | FBG | 4 | 190 | 43.70% | 0.149 | Fixed | −8.29 (−15.19 to −1.39) | 0.019 |
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SCr, serum creatinine; BUN, blood urea nitrogen; PRO, proteinuria; TC, total cholesterol; TG, triglycerides; LDL-C, low-density lipoprotein-cholesterol; HDL-C, high-density lipoprotein-cholesterol; SBP, systolic blood pressure; DBP, diastolic blood pressure; FBG, fasting blood glucose.
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