Ethanolic Fruit Extract of Emblica officinalis Suppresses Neuroinflammation in Microglia and Promotes Neurite Outgrowth in Neuro2a Cells

Figure 9

Proposed pathways involved in neuroprotective and anti-inflammatory activities of Emblica officinalis. (a) EO crude fruit extract significantly attenuated proinflammatory cytokine IL-6, NO, and TNF-α in LPS-induced BV2 cells via the ERK1/2 and JNK signaling pathways. (b) Neuroprotective effects are associated with enhanced neurite outgrowth that the TuJ1 and MAP2 mRNA expressions may influence.

(a)

(b)