Network Pharmacology Integrated with Molecular Docking Explores the Mechanisms of Naringin against Osteoporotic Fracture by Regulating Oxidative Stress

Table 4

Molecular interactions of core targets and naringin.

Compound	Target	Affinity (kcal/mol)	Number of hydrogen bonds	Hydrogen bonds interacting residues
Naringin	ESR1	−7.1	3	Thr-347(2), Leu-525
Naringin	CASP3	−5.4	9	Arg-179, Gln-283, Tyr-338(2), Arg-341(4), Ser-343
Naringin	ACE	−9.4	8	Glu-162, Gln-281, Ala-354(2), His-383, Lys-449, Lys-454, His-513
Naringin	TNF	−6.5	3	Gly-121, Gly-148, Gln-149
Naringin	PPARG	−9.1	6	Ala-278, Ile-281, Gln-286, Ser-289(2), Glu-343
Naringin	SERPINE1	−7.2	5	Tyr-37, Arg-76, Tyr-79, Asp-95, Arg-118
Naringin	CYP19A1	−9.0	7	Arg-115(2), Thr-310, Ser-314, Leu-372, Phe-430, Gly-439
Naringin	MMP1	−9.5	5	Asn-180, Leu-181, Ala-182(2), Glu-219