GDF-15 Suppresses Atherosclerosis by Inhibiting oxLDL-Induced Lipid Accumulation and Inflammation in Macrophages

Figure 7

Effect of recombinant GDF-15 on high-fat fed ApoE^−/− mice: (a) representative H&E staining images of artery vessels in WT mice, ApoE^−/− mice, and recombinant GDF-15-treated ApoE^−/− mice; (b) representative IL-6 immunohistochemical staining images of artery vessels in WT mice, ApoE^−/− mice, and recombinant GDF-15-treated ApoE^−/− mice; (c) expressions of CD36, LOX1, and TLR4 in artery vessels of WT mice, ApoE^−/− mice, and recombinant GDF-15-treated ApoE^−/− mice; and (d) levels of IL-6, IL-8, MCP-1, and MMP9 in artery vessels of each group. Values are expressed as the mean ± standard deviation of three independent experiments of five independent animal samples as determined by one-way ANOVA test. vs. WT control group; vs. ApoE^−/− model group.

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