Hydromethanolic Crude Extract of the Leaf of Urtica simensis Hochst. ex. A. Rich. (Urticaceae) Acquires Appreciable Antiulcer Effect: Validation for In Vivo Antiulcer Activity

Table 3

The effect of Urtica simensis on gastric secretion, full acidity, and pH in pylorus-ligated rats.

Class	Therapy	Dosage	GI secretion (ml)	Depletion (%)	Full acidity (mEq/L)	Depletion (%)	PH
I	Distilled H2O	10 ml/kg/day	4.73 ± 0.17	0.00	57.16 ± 0.93	0.00	1.76 ± 0.16
II	Omeprazole	20 mg/kg/day	2.07 ± 0.07^w3	56.24	17.02 ± 0.42^w3	70.22	6.09 ± 0.17^w3
III	U. simensis	100 mg/kg/day	3.72 ± 0.23^w2	21.35	19.49 ± 0.38^w3	65.90	4.67 ± 0.26^w3
IV	U. simensis	200 mg/kg/day	2.79 ± 0.25^w3	41.01	17.69 ± 0.38^w3	69.05	5.79 ± 0.12^w3
V	U. simensis	400 mg/kg/day	1.93 ± 0.05^w3	59.20	16.73 ± 0.15^w3	70.73	6.09 ± 0.099^w3

Note. Each value represents mean ± SEM; n = 6; ^w: against class I; ²: , ³: ; SEM: standard error of the mean.