Hydromethanolic Crude Extract of the Leaf of Urtica simensis Hochst. ex. A. Rich. (Urticaceae) Acquires Appreciable Antiulcer Effect: Validation for In Vivo Antiulcer Activity

Table 6

Effects of ulcer score and ulcer index on an acetic acid-induced ulcer in rats.

Class	Treatment	Dose	Ulcer score	% change US	Ulcer index	% change UI
I	Distilled H2O	10 ml/kg/day	82.92 ± 1.63	0.00	22.99 ± 0.27	0.00
II	Cimetidine	100 mg/kg/day	10.67 ± 3.40^w3	87.13	8.20 ± 2.59^w3	64.33
III	U. simensis	100 mg/kg/day	34.42 ± 1.47^w3x3y3z3	58.49	15.31 ± 0.37^w1z1	33.54
IV	U. simensis	200 mg/kg/day	11.00 ± 2.51^w3	86.73	9.58 ± 1.92^w3	58.33
V	U. simensis	400 mg/kg/day	6.33 ± 2.02^w3	92.34	7.57 ± 2.39^w3	67.07

Note. Each value indicates mean ± SEM; n = 6; ^w: against class I; ^x: against class II; ^y: against class IV; ^z: against class V; ¹: , ²: , ³: ; SEM: standard error of the mean.