Resveratrol Ameliorates High-Fat-Diet-Induced Abnormalities in Hepatic Glucose Metabolism in Mice via the AMP-Activated Protein Kinase Pathway

Figure 2

Resveratrol improves serum glucose and protects against HFD-induced insulin resistance. Serum levels of blood glucose, insulin, insulin sensitivity, and OGTT were measured after 8 weeks of treatment. The insulin sensitivity index (ISI) was measured according to the formula ISI = 1/(fasting insulin × fasting plasma glucose). The HOMA-IR index of IR was determined as follows: blood glucose (mmol/L) × serum insulin (mg/ml)/22.5. Pretreatment with resveratrol, RE-L (60 mg/kg), RE-M (80 mg/kg), and RE-H (100 mg/kg). The data shown represent the means ± SEM. , .

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