A 90-Day Oral Toxicity Study of an Ethanolic Root Extract of Caesalpinia bonduc (L.) Roxb. in Wistar Rats

Table 2

Effects of ethanolic root extract of Caesalpinia bonduc on hematological parameters of rats after 90-day oral treatment.

Parameters	Control	31.25 mg/kg	125 mg/kg	500 mg/kg
Hemoglobin (g/dL)	16.27 ± 0.27	14.57 ± 0.50	15.70 ± 0.56	18.02 ± 0.43
Hematocrit (%)	58.50 ± 1.06	61.33 ± 2.65	55.67 ± 2.55	53.50 ± 3.00
Erythrocytes (T/L)	7.65 ± 0.40	6.40 ± 0.22	8.26 ± 0.20	9.19 ± 0.43^a
MGV (fL)	72.67 ± 2.24	68.83 ± 2.50	66.50 ± 1.73	70.33 ± 1.80
MCH (pg)	22.83 ± 1.25	25.17 ± 1.14	23.50 ± 1.00	20.00 ± 0.73
MCHC (%)	30.50 ± 1.31	27.17 ± 2.30	32.67 ± 1.61	29.33 ± 1.10
Leucocytes (G/L)	11.88 ± 0.50	10.43 ± 0.40	11.25 ± 0.60	12.58 ± 1.00
Neutrophil (G/L)	5.82 ± 0.56	4.14 ± 0.26^a	6.42 ± 0.33	5.40 ± 0.31
Eosinophil (G/L)	0.58 ± 0.05	0.42 ± 0.08	0.63 ± 0.06	0.56 ± 0.07
Monocyte (G/L)	0.67 ± 0.08	0.92 ± 0.06	0.75 ± 0.04	0.82 ± 0.14
Lymphocyte (G/L)	4.83 ± 0.17	5.64 ± 0.41	5.30 ± 0.30	6.54 ± 1.00
Platelet (10^3/μL)	647.30 ± 27.57	567.20 ± 23.40	692.30 ± 23.50	725.50 ± 18.00

Values are mean ± SEM, mean globular volume (MGV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC). “a” indicates significance () from control group.