A 90-Day Oral Toxicity Study of an Ethanolic Root Extract of Caesalpinia bonduc (L.) Roxb. in Wistar Rats

Table 3

Effects of ethanolic root extract of Caesalpinia bonduc on biochemical parameters of rats after 90-day oral treatment.

Parameters	Control	31.25 mg/kg	125 mg/kg	500 mg/kg
Glucose (G/L)	0.62 ± 0.06	0.51 ± 0.03	0.49 ± 0.02	0.46 ± 0.05^a
Urea (G/L)	0.71 ± 0.06	0.62 ± 0.05	0.58 ± 0.03	0.66 ± 0.02
Creatinine (mg/L)	6.22 ± 0.35	6.05 ± 0.50	5.63 ± 0.20	5.45 ± 0.40
Total cholesterol (G/L)	0.67 ± 0.04	0.71 ± 0.03	0.73 ± 0.05	0.81 ± 0.03^a
Total protein (G/L)	37.15 ± 0.55	38.07 ± 1.00	40.51 ± 1.25	40.97 ± 0.52
AST (UI/L)	150.50 ± 2.30	158.70 ± 3.00	163.80 ± 3.40^a	171.30 ± 4.00^a
ALT (UI/L)	86.33 ± 4.04	75.67 ± 2.01	78.67 ± 3.50	95.17 ± 4.00
Sodium (mEq/L)	141.20 ± 3.70	143.00 ± 3.00	137.20 ± 4.40	139.50 ± 3.37
Potassium (mEq/L)	3.80 ± 0.14	4.13 ± 0.32	4.56 ± 0.40	4.76 ± 0.50
Chloride (mEq/L)	108.70 ± 1.20	107.50 ± 1.60	109.20 ± 0.70	108.30 ± 1.05

Values are mean ± SEM, aspartate aminotransferase (AST), alanine aminotransferase (ALT). “a” indicates significance () from control group.