Research Article
Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)
Table 1
Predicted toxicity and pharmacokinetic profile of the isolated compounds.
| Compound | Mutagenicity by Ames test | Oral rat LD50 (mg/kg) | Consensus Log P o/w | Solubility (mg/mL) | GI absorption | Log kp (skin permeation) cm/s | BBB permeant |
| 1 | Negative | 620 | 2.82 | 3.77e − 02 | High | −5.03 | Yes | 2 | Positive | 303 | 2.15 | 3.42e − 02 | High | −6.52 | No | 3 | Negative | 680 | 1.69 | 1.85 | High | −8.45 | No | 4 | Negative | 680 | 1.63 | 1.85 | High | −8.45 | No |
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