Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)

Table 1

Predicted toxicity and pharmacokinetic profile of the isolated compounds.

Compound	Mutagenicity by Ames test	Oral rat LD50 (mg/kg)	Consensus Log P o/w	Solubility (mg/mL)	GI absorption	Log kp (skin permeation) cm/s	BBB permeant
1	Negative	620	2.82	3.77e − 02	High	−5.03	Yes
2	Positive	303	2.15	3.42e − 02	High	−6.52	No
3	Negative	680	1.69	1.85	High	−8.45	No
4	Negative	680	1.63	1.85	High	−8.45	No